Two different Web-based interventions were developed aimed at reducing chronic cancer-related fatigue (CCRF): a physiotherapist-guided ambulant activity feedback (AAF) therapy encompassing the use of an accelerometer, and a psychologist guided Web-based mindfulness-based cognitive therapy (eMBCT). In conclusion, AAF and eMBCT are effective interventions for reducing fatigue and improve mental health, as they help increasing sense of control of fatigue through providing helpful tools and being guided by a professional and caring therapist. The interventions helped patients’ reorientation of their identity as they gained insights in their boundaries and pitfalls.