Although the Youth Self-Report (YSR) has been used in many studies throughout the world, little is known about the equivalence of the factor structure of this instrument for immigrant adolescents. Measurement invariance of the three internalizing syndrome scales of the YSR was tested across four ethnic groups (native Dutch, Surinamese, Turkish, Moroccan) and over time. Results of the present study showed that the scales were invariant across all ethnic groups and over time. Together, the results indicated that the YSR can be used for developmental studies in these immigrant populations.